Primary Research Manuscripts (since 2016)
Woodlief T, Vance S, Hu Q, DeWitt J. 2021. Immunotoxicity of per- and polyfluoroalkyl substances: Insights into short-chain PFAS exposure. Toxics. 9:100.
Zhou J, Baumann K, Mead RN, Skrabal SA, Kieber RJ, Avery GB, Shimizu M, DeWitt JC, Sun M, Vance SA, Bodnar W, Zhang Z. 2021. PFOS dominates PFAS composition in ambient fine particulate matter (PM2.5) collected across North Carolina nearly 20 years after the end of its US production. Environmental Science: Processes and Impacts. 23:580-587.
Jiang Q, Xu X, DeWitt JC, Zheng Y. 2021. Using chicken embryo as a powerful tool in assessment of developmental cardiotoxicities. Journal of Visualized Experiments, 21:doi: 10.3791/62189.
McDonough C, Ward C, Hu Q, Vance S, Higgins C, DeWitt J. 2020. Immunotoxicity of an electrochemically fluorinated aqueous film-forming foam. Toxicological Sciences, 178:104-114.
vonderEmbse A, Gomez I, Hu Q, DeWitt J. 2020. Postnatal toxicant exposure in 3xTgAD mice promotes detrimental, sex-dependent NeuroimmiR profiles for microglia:neuron crosstalk. Neuroimmunology and Neuroinflammation. 7:345-359.
Kotlarz N, McCord J, Collier D, Lea CS, Strynar M, Lindstrom AB, Wilkie AA, Islam JY, Matney K, Tarte P, Polera ME, Burdette K, DeWitt J, May K, Smart RC, Knappe DRU, Hoppin JA. 2020. Poorly understood PFAS generated as byproducts of fluorochemical manufacturing are in the blood of children and adults living in Wilmington, North Carolina. Environmental Health Perspectives. DOI: 10.1289/EHP6837.
McDonough C, Choyke S, Ferguson PL, DeWitt J, Higgins C. 2020. Bioaccumulation of novel per- and polyfluoroalkyl substances (PFASs) in mice dosed with an aqueous film-forming foam (AFFF). 2020. Environmental Science & Technology. 54:5700-5709.
vonderEmbse AN, Hu Q, DeWitt JC. 2019. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer’s disease. International Immunopharmacology. 71:241-250.
Keil DE, Buck B, Goossens D, McLaurin B, Murphy L, Leetham-Spencer M, Teng Y, Pollard J, Gerads R, and DeWitt JC. 2018. Nevada desert dust with heavy metals suppresses IgM antibody production. Toxicology Reports. 5:258-269.
vonderEmbse AN, Hu Q, and DeWitt JC. 2017. Developmental toxicant exposure in a mouse model of Alzheimer’s disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation. Journal of Developmental Origins of Health and Disease. 2:1-9.
Meadows JR, Parker C, Gilbert KM, Blossom SJ, and DeWitt JC. 2017. A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice. Journal of Immunotoxicology. 14:95-102.
DeWitt JC, Buck BJ, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, and DE Keil. 2017. Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV). Toxicology Reports. 4:19-31.
Rushing BR, Hu Q, Franklin JN, McMahen R, Dagnino S, Higgins CP, Strynar MJ, and DeWitt JC. 2017. Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice. Toxicological Sciences. doi: 10.1093/toxsci/kfw251.
Keil DE, Buck B, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, DeWitt JC. 2016. Health effects from exposure to atmospheric mineral dust near Las Vegas, NV, USA. Toxicology Reports. 3:785-795.
Jusko TA, Oktapoda M, Murinová LP, Babjaková J, Verner M-A, DeWitt JC, Babinská, Thevenet-Morrison K, Conka K, Drobná B, Thurston SW, Lawrence BP, Dozier AM, Jarvinene-Seppo KM, Patayová H, Trnovec T, Legler J, Hertz-Picciotto I, and Lamoree MH. 2016. Demographic, reproductive, and dietary determinants of perfluorooctane sulfonic (PFOS) and perfluooctanoic acid (PFOA) concentrations in human colostrum. Environmental Science and Technology. 50:7152-7162.
DeWitt JC, Buck B, Goossens D, Hu Q, Chow R, David W, Young S, Teng Y, Leetham-Spencer M, Murphy L, Pollard J, McLaurin B, Gerads R, and Keil D. 2016. Health effects following subacute exposure to dusts from arsenic-rich sediment at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology. 304:79-89.
Leetham M, DeWitt J, Buck B, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, and Keil D. 2016. Oxidative stress and lung pathology following geogenic dust exposure. Journal of Applied Toxicology. 36:1276-1283.
Keil D, Buck B, Goossens D, Teng Y, Spencer M, Murphy L, Pollard J, Eggers M, Gerards R, and DeWitt J. 2016. Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology, 291:1-12.
DeWitt JC, Williams W, Creech NJ, and RW Luebke. 2016. Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARa and B cell targeting. Journal of Immunotoxicology. 13:38-45.
Jiang Q, Ma W, Wu J, Wingard CJ, and DeWitt JC. 2016. Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes. Environmental Toxicology. 31:1580-1590.
Khalil N, Chen A, Lee M, Czerwinski SA, Ebert JR, DeWitt JC, and Kannan K. 2016. Association of perfluoroalkyl substances, bone mineral density, and osteoporosis in the US population in NHANES 2009-2010. Environmental Health Perspectives. 124:81-87.
Cousins IT, DeWitt JC, Lohmann R, Glüge J, Goldenman G, Herzke D, Ng CA, Scheringer M, Wang Z. 2020. The high persistence of PFAS is sufficient for their management as a chemical class. Environmental Science: Processes & Impacts, 22:2307-2312.
Lohman R, Cousins I, DeWitt J, Glüge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z. 2020. Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS? Environmental Science & Technology, 54:12820-12828.
Glüge J, Scheringer S, Cousins IT, DeWitt JC, Goldenman G, Herzke D, Lindstrom AB, Lohmann R, Ng CA, Trier X, Wang Z. 2020. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Accepted by Environmental Science: Processes & Impacts, 22:2345-2373.
Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, Smith JS, and Roberts SM. 2020. Per- and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research. Environmental Toxicology and Chemistry, https://doi.org/10.1002/etc.4890.
Kwiatkowski C, Andrews D, Birnbaum L, Bruton T, DeWitt J, Knappe D, Maffini M, Miller M, Pelch K, Reade A, Soehl A, Trier X, Venier M, Wagner C, Wang Z, and Blum A. 2020. The scientific basis for managing PFAS as a chemical class. Environmental Science and Technology Letters. DOI: 10.1021/acs.estlett.0c00255.
Cousins IT, DeWitt JC, Glüge J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Vierke L, and Wang Z. 2020. Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health. Environmental Science: Processes & Impacts. DOI: 10.1039/d0em00147c.
Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Scheringer M, Trier X, Vierke L, Wang Z, DeWitt JC. 2019. The concept of essential use for determining when uses of PFASs can be phased out. Environmental Science: Processes & Impacts. 21:1803-1815.
DeWitt JC, Blossom SJ, and Schaider L. 2019. Exposure to per- and polyfluoroalkyl substances leads to immunotoxicity: Epidemiological and toxicological evidence. Accepted to the Journal of Exposure Science and Environmental Epidemiology (invited).
Hopkins ZR, Sun M, DeWitt JC, and Knappe DRU. 2018. New drinking water contaminants: GenX and other per- and polyfluoroalkyl ether acids. Journal AWWA.
DeWitt JC and Patisaul HB. 2018. Endocrine disruptors and the developing immune system. Current Opinion in Toxicology. 10:31-36.
Wang Z, DeWitt JC, Higgins CP, and Cousins IT. 2017. A never-ending story of per- and polyfluoroalkyl substances (PFASs)? Environmental Science and Technology. 51:2508-2518.
Hessel EVS, Ezendam J, van Broekhuizen FA, Hakkert B, DeWitt JC, Granum B, Guzylack L, Lawrence BP, Penninks A, Rooney AA, Piersma AH, and van Loveren H. 2016. Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. Reproductive Toxicology. 65:448-456.
Meadows JR, DeWitt JC, and Rooney AA. 2018. Ecoimmunotoxicology – An overview. In: Comprehensive Toxicology (McQueen CA, ed) 3rd edition. Elsevier Ltd., Oxford.
DeWitt JC and Keil DE. 2017. Current issues in developmental immunotoxicity. In: Immunopathology in Toxicology and Drug Development (Parker G.A, ed). Springer International Publishing, Switzerland.
DeWitt JC, Germolec DR, Luebke RW, and Johnson, VJ. 2016. Associating changes in the immune system with clinical diseases for interpretation of risk assessment. In: Current Protocols in Toxicology. 67:18.1.1-18.1.22.
Other Scholarly Contributions
DeWitt JC, Rockwell CE, and Bowman CC (eds). 2018. Immunotoxicity Testing: Methods and Protocols, Methods in Molecular Biology Series. Springer Science + Business Media, LLC.
Portier CJ et al. (90+ co-authors). 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). Journal of Epidemiology and Community Health. 70:741-745.