Publications

Primary Research Manuscripts (since 2017)
Barton KE, Zell-Baran LM, DeWitt JC, Brindley S, McDonough CA, Higgins CP, Adgate JL, and Starling AP. 2022. Cross-sectional associations between serum PFASs and inflammatory biomarkers in a population exposed to AFFF-contaminated drinking water. International Journal of Hygiene and Environmental Health. 240:113905.

Woodlief T, Vance S, Hu Q, DeWitt J. 2021. Immunotoxicity of per- and polyfluoroalkyl substances: Insights into short-chain PFAS exposure. Toxics. 9:100.

Zhou J, Baumann K, Mead RN, Skrabal SA, Kieber RJ, Avery GB, Shimizu M, DeWitt JC, Sun M, Vance SA, Bodnar W, Zhang Z. 2021. PFOS dominates PFAS composition in ambient fine particulate matter (PM_2.5) collected across North Carolina nearly 20 years after the end of its US production. Environmental Science: Processes and Impacts. 23:580-587.

Jiang Q, Xu X, DeWitt JC, Zheng Y. 2021. Using chicken embryo as a powerful tool in assessment of developmental cardiotoxicities. Journal of Visualized Experiments, 21:doi: 10.3791/62189.

McDonough C, Ward C, Hu Q, Vance S, Higgins C, DeWitt J. 2020. Immunotoxicity of an electrochemically fluorinated aqueous film-forming foam. Toxicological Sciences, 178:104-114.

vonderEmbse A, Gomez I, Hu Q, DeWitt J. 2020. Postnatal toxicant exposure in 3xTgAD mice promotes detrimental, sex-dependent NeuroimmiR profiles for microglia:neuron crosstalk. Neuroimmunology and Neuroinflammation. 7:345-359.

Kotlarz N, McCord J, Collier D, Lea CS, Strynar M, Lindstrom AB, Wilkie AA, Islam JY, Matney K, Tarte P, Polera ME, Burdette K, DeWitt J, May K, Smart RC, Knappe DRU, Hoppin JA. 2020. Poorly understood PFAS generated as byproducts of fluorochemical manufacturing are in the blood of children and adults living in Wilmington, North Carolina. Environmental Health Perspectives. DOI: 10.1289/EHP6837.

McDonough C, Choyke S, Ferguson PL, DeWitt J, Higgins C. 2020. Bioaccumulation of novel per- and polyfluoroalkyl substances (PFASs) in mice dosed with an aqueous film-forming foam (AFFF). 2020. Environmental Science & Technology. 54:5700-5709.

vonderEmbse AN, Hu Q, DeWitt JC. 2019. Dysfunctional microglia:neuron interactions with significant female bias in a developmental gene x environment rodent model of Alzheimer’s disease. International Immunopharmacology. 71:241-250.

Keil DE, Buck B, Goossens D, McLaurin B, Murphy L, Leetham-Spencer M, Teng Y, Pollard J, Gerads R, and DeWitt JC. 2018. Nevada desert dust with heavy metals suppresses IgM antibody production. Toxicology Reports. 5:258-269.

vonderEmbse AN, Hu Q, and DeWitt JC. 2017. Developmental toxicant exposure in a mouse model of Alzheimer’s disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation. Journal of Developmental Origins of Health and Disease. 2:1-9.

Meadows JR, Parker C, Gilbert KM, Blossom SJ, and DeWitt JC. 2017. A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice. Journal of Immunotoxicology. 14:95-102.

DeWitt JC, Buck BJ, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, and DE Keil. 2017. Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV). Toxicology Reports. 4:19-31.

Rushing BR, Hu Q, Franklin JN, McMahen R, Dagnino S, Higgins CP, Strynar MJ, and DeWitt JC. 2017. Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice. Toxicological Sciences. doi: 10.1093/toxsci/kfw251.

Reviews/Commentaries (since 2017)
Ducatman A, LaPier J, Fuoco R, DeWitt JC. 2022. Official health communications are failing PFAS-contaminated communities. Environmental Health. 21:51.

McDonough C, Wenting L, Bischel H, DeSilva A, and DeWitt J. 2022. Widening the lens on PFASs: Direct human exposure on perfluoroalkyl precursors (pre-PFAAs). Environmental Science and Technology. 17:6004-6013.

Glüge J, London R, Cousins IT, DeWitt J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Trier X, Wang Z, and Scheringer M. 2021. Information requirements under the essential-use concept: PFAS case studies. Environmental Science and Technology. https://doi.org/10.1021/acs.est.1c03732.

Cousins IT, DeWitt JC, Glüge J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Scheringer M, Trier X, and Wang Z. 2021. Finding essentiality feasible: Common questions and misinterpretations concerning the “essential use” concept. Environmental Science: Processes & Impacts. 23:1079-1087.

Ng C, Cousins IT, DeWitt JC, Glüge J, Goldenman G, Herzke D, Lohmann R, Miller M, Patton S, Scheringer M, Trier X, and Wang Z. 2021. Addressing urgent questions for PFAS in the 21^st century. Environmental Science & Technology. https://doi.org/10.1021/acs.est.1c03386.

Cousins IT, DeWitt JC, Lohmann R, Glüge J, Goldenman G, Herzke D, Ng CA, Scheringer M, Wang Z. 2020. The high persistence of PFAS is sufficient for their management as a chemical class. Environmental Science: Processes & Impacts, 22:2307-2312.

Lohman R, Cousins I, DeWitt J, Glüge J, Goldenman G, Herzke D, Lindstrom A, Miller M, Ng C, Patton S, Scheringer M, Trier X, Wang Z. 2020. Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS? Environmental Science & Technology, 54:12820-12828.

Glüge J, Scheringer S, Cousins IT, DeWitt JC, Goldenman G, Herzke D, Lindstrom AB, Lohmann R, Ng CA, Trier X, Wang Z. 2020. An overview of the uses of per- and polyfluoroalkyl substances (PFAS). Accepted by Environmental Science: Processes & Impacts, 22:2345-2373.

Fenton SE, Ducatman A, Boobis A, DeWitt JC, Lau C, Ng C, Smith JS, and Roberts SM. 2020. Per- and polyfluoroalkyl substance toxicity and human health review: Current state of knowledge and strategies for informing future research. Environmental Toxicology and Chemistry, https://doi.org/10.1002/etc.4890.

Kwiatkowski C, Andrews D, Birnbaum L, Bruton T, DeWitt J, Knappe D, Maffini M, Miller M, Pelch K, Reade A, Soehl A, Trier X, Venier M, Wagner C, Wang Z, and Blum A. 2020. The scientific basis for managing PFAS as a chemical class. Environmental Science and Technology Letters. DOI: 10.1021/acs.estlett.0c00255.

Cousins IT, DeWitt JC, Glüge J, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Scheringer M, Vierke L, and Wang Z. 2020. Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health. Environmental Science: Processes & Impacts. DOI: 10.1039/d0em00147c.

Cousins IT, Goldenman G, Herzke D, Lohmann R, Miller M, Ng CA, Patton S, Scheringer M, Trier X, Vierke L, Wang Z, DeWitt JC. 2019. The concept of essential use for determining when uses of PFASs can be phased out. Environmental Science: Processes & Impacts. 21:1803-1815.

DeWitt JC, Blossom SJ, and Schaider L. 2019. Exposure to per- and polyfluoroalkyl substances leads to immunotoxicity: Epidemiological and toxicological evidence. Accepted to the Journal of Exposure Science and Environmental Epidemiology (invited).

Hopkins ZR, Sun M, DeWitt JC, and Knappe DRU. 2018. New drinking water contaminants: GenX and other per- and polyfluoroalkyl ether acids.  Journal AWWA.

DeWitt JC and Patisaul HB. 2018. Endocrine disruptors and the developing immune system. Current Opinion in Toxicology. 10:31-36.

Ritscher A, Wang Z, Scheringer M, Boucher JM, Ahrens L, Berger U, et al. 2018. Zürich statement on future actions on per- and polyfluoroalkyl substances (PFASs). Environmental Health Perspectives. 126: https://doi.org/10.1289/EHP4158.

Wang Z, DeWitt JC, Higgins CP, and Cousins IT. 2017. A never-ending story of per- and polyfluoroalkyl substances (PFASs)? Environmental Science and Technology. 51:2508-2518.

Book Chapters (since 2017)
vonderEmbse AN and DeWitt JC. 2018. Developmental immunotoxicity (DIT) testing: Current recommendations and the future of DIT testing. In: Immunotoxicity Testing: Methods and Protocols (DeWitt JC, Rockwell CE, and Bowman CC, eds), Methods in Molecular Biology Series. Springer Science + Business Media, LLC.

Meadows JR, DeWitt JC, and Rooney AA. 2018. Ecoimmunotoxicology – An overview. In: Comprehensive Toxicology (McQueen CA, ed) 3^rd edition. Elsevier Ltd., Oxford.

DeWitt JC and Keil DE. 2017. Current issues in developmental immunotoxicity. In: Immunopathology in Toxicology and Drug Development (Parker G.A, ed). Springer International Publishing, Switzerland.

Other Scholarly Contributions (since 2017)
DeWitt JC, Rockwell CE, and Bowman CC (eds). 2018. Immunotoxicity Testing: Methods and Protocols, Methods in Molecular Biology Series. Springer Science + Business Media, LLC.