Publications

Peer-Reviewed Manuscripts (since 2006)
vonderEmbse AN, Hu Q, and DeWitt JC. Developmental toxicant exposure in a mouse model of Alzheimer’s disease induces differential sex-associated microglial activation and increased susceptibility to amyloid accumulation. Accepted to the Journal of Developmental Origins of Health and Disease.

Meadows JR, Parker C, Gilbert KM, Blossom SJ, and DeWitt JC. 2017. A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice. Journal of Immunotoxicology. 14:95-102.

DeWitt JC, Buck BJ, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, and DE Keil. 2017. Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV). Toxicology Reports. 4:19-31.

Rushing BR, Hu Q, Franklin JN, McMahen R, Dagnino S, Higgins CP, Strynar MJ, and DeWitt JC. 2017. Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate in C57BL/6 mice. Toxicological Sciences. doi: 10.1093/toxsci/kfw251.

Keil DE, Buck B, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, DeWitt JC. 2016. Health effects from exposure to atmospheric mineral dust near Las Vegas, NV, USA. Toxicology Reports. 3:785-795.

Jusko TA, Oktapoda M, Murinová LP, Babjaková J, Verner M-A, DeWitt JC, Babinská, Thevenet-Morrison K, Conka K, Drobná B, Thurston SW, Lawrence BP, Dozier AM, Jarvinene-Seppo KM, Patayová H, Trnovec T, Legler J, Hertz-Picciotto I, and Lamoree MH. 2016. Demographic, reproductive, and dietary determinants of perfluorooctane sulfonic (PFOS) and perfluooctanoic acid (PFOA) concentrations in human colostrum. Environmental Science and Technology. 50:7152-7162.

DeWitt JC, Buck B, Goossens D, Hu Q, Chow R, David W, Young S, Teng Y, Leetham-Spencer M, Murphy L, Pollard J, McLaurin B, Gerads R, and Keil D. 2016. Health effects following subacute exposure to dusts from arsenic-rich sediment at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology. 304:79-89.

Leetham M, DeWitt J, Buck B, Goossens D, Teng Y, Pollard J, McLaurin B, Gerads R, and Keil D. 2016. Oxidative stress and lung pathology following geogenic dust exposure. Journal of Applied Toxicology. 36:1276-1283.

Keil D, Buck B, Goossens D, Teng Y, Spencer M, Murphy L, Pollard J, Eggers M, Gerards R, and DeWitt J. 2016. Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV. Toxicology and Applied Pharmacology, 291:1-12.

DeWitt JC, Williams W, Creech NJ, and RW Luebke. 2016. Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARa and B cell targeting. Journal of Immunotoxicology. 13:38-45.

Jiang Q, Ma W, Wu J, Wingard CJ, and DeWitt JC. 2016. Perfluorooctanoic acid-induced toxicity in primary cultures of chicken embryo cardiomyocytes. Environmental Toxicology. 31:1580-1590.

Khalil N, Chen A, Lee M, Czerwinski SA, Ebert JR, DeWitt JC, and Kannan K. 2016. Association of perfluoroalkyl substances, bone mineral density, and osteoporosis in the US population in NHANES 2009-2010. Environmental Health Perspectives. 124:81-87.

Wambaugh JF, Setzer W, Pitruzzello AM, Liu J, Reif D, Kleinstreuer N, Ching N, Wang Y, Sipes N, Martin M, Das K, DeWitt J, Strynar M, Judson R, Houck K, and Lau C. 2013. Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate. Toxicological Sciences. 136:308-327.

Jiang Q, Lust R, and DeWitt JC. 2013. Perflurooctanoic acid induced-developmental cardiotoxicity: Are peroxisome proliferator activated receptor a (PPARa) and bone morphorgenic protein 2 (BMP2) pathways involved? Journal of Toxicology and Environmental Health Part A. 76:635-650.

Hu Q, Franklin JN, Bryan I, Morris E, Wood A, and DeWitt JC. 2012. Does developmental exposure to perflurooctanoic acid (PFOA) induce immunopathologies commonly observed in neurodevelopmental disorders? NeuroToxicology. 33:1491-1498.

Jiang Q, Lust R, Strynar MJ, and DeWitt JC. 2012. Perflurooctanoic acid induces developmental cardiotoxicity in chicken embryos and hatchlings. Toxicology. 293:97-106.

Fair PA, Stavros H-C, Mollenhauer MAM, DeWitt JC, Henry N, Kannan K, Mitchum G, Y SH, Bossart GD, Keil DE, and Peden-Adams MM. 2012. Immune function in female B6C3F1 mice is modulated by DE-71, a commercial polybrominated diphenyl ether mixture. Journal of Immunotoxicology. 9:96-107.

Hu Q, Strynar MJ, and DeWitt JC. 2010. Are developmentally exposed C57BL/6 mice insensitive to suppression of TDAR by PFOA? Journal of Immunotoxicology. 7:344-349.

DeWitt JC, Copeland CB, and Luebke RW. 2009. Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice. Toxicological Sciences. 109:106-112.

Peden-Adams MM, Stuckey JE, Gaworecki K, Berger-Ritchie J, Bryant K, Jodice PG, Scott TR, Boone S, McGuinn WD, DeWitt JC, and Keil DE. 2009. Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS). Reproductive Toxicology. 27:307-318.

Whalen MM, DeWitt JC, Luebke RW. 2008. Serum supplementation modulates the effects of dibutyltin on human natural killer cell function. Toxicological Sciences. 104:312-319.

DeWitt JC, Copeland CB, Strynar MJ, and Luebke RW. 2008. Perflurooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice. Environmental Health Perspectives. 116:644-650.

DeWitt JC, Copeland CB, and Luebke RW. 2008. An organotin mixture found in polyvinyl chloride (PVC) pipe is not immunotoxic to adult Sprague-Dawley rats. Journal of Toxicology and Environmental Health Part A. 71:276-282.

 DeWitt JC, Copeland CB, and Luebke RW. 2007. Immune function is not impaired in Sprague-Dawley rats exposed to dimethyltin dichloride (DMTC) during development or adulthood. Toxicology. 232:303-310.

Lim J, DeWitt JC, Sanders RA, Watkins JB III, and Henshel DS. 2007. Suppression of endogenous anti-oxidant enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin-Induced oxidative stress in chicken liver during development. Archives of Environmental Contamination and Toxicology. 52:590-595.

DeWitt JC, Copeland CB, and Luebke RW. 2006. Developmental exposure to 1.0 or 2.5 mg/kg of dibutyltin dichloride does not impair immune function in Sprague-Dawley rats. Journal of Immunotoxicology. 3:245-252.

DeWitt JC, Millsap DS, Yeager RL, Heise SS, Sparks DW, and Henshel, DS. 2006. External heart deformities in passerine birds exposed to environmental mixtures of polychlorinated biphenyls during development. Environmental Toxicology and Chemistry. 25:541-551.

Review Articles
Wang Z, DeWitt JC, Higgins CP, and Cousins IT. 2017. A never-ending story of per- and polyfluoroalkyl substances (PFASs)? Environmental Science and Technology. 51:2508-2518.

Hessel EVS, Ezendam J, van Broekhuizen FA, Hakkert B, DeWitt JC, Granum B, Guzylack L, Lawrence BP, Penninks A, Rooney AA, Piersma AH, and van Loveren H. 2016. Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI. Reproductive Toxicology. 65:448-456.

Corsini E, Luebke RW, Germolec DR, and DeWitt JC. 2014. Perfluorinated compounds: emerging POPs with potential immunotoxicity. Toxicology Letters, 230:263-270.

DeWitt J, Peden-Adams M, Keller J, and Germolec D. 2012. The immunotoxicity of perfluorinated compounds: Recent developments. Toxicologic Pathology, 40:300-311.

DeWitt J, Peden-Adams M, Keil D, and Dietert R. 2012. Current status of developmental immunotoxicity: Early-life patterns and testing. Toxicologic Pathology, 40:230-236.

Dietert RR, Dietert J, and DeWitt JC. 2011. Environmental risk factors for autism. Emerging Health Threats Journal (invited review). 4:7111.

Dietert RR, DeWitt JC, Germolec DR, and Zelikoff JT. 2010. Breaking patterns of environmentally influenced disease for health risk reduction: Immune perspectives. Environmental Health Perspectives 118:1091-1099.

DeWitt JC, Shnyra A, Badr MZ, Loveless SE, Hoban D, Frame SR, Cunard R, Anderson SE, Meade BJ, Peden-Adams MM, Luebke RW, and Luster MI. 2009. Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator activated receptor alpha. Critical Reviews in Toxicology 39:76-94.

Book Chapters
DeWitt JC and Keil DE. 2017. Current issues in developmental immunotoxicity. In: Immunopathology in Toxicology and Drug Development (Parker G.A, ed). Springer International Publishing, Switzerland.

DeWitt JC, Germolec DR, Luebke RW, and Johnson, VJ. 2016. Associating changes in the immune system with clinical diseases for interpretation of risk assessment. In: Current Protocols in Toxicology. 67:18.1.1-18.1.22.

DeWitt JC, Peden-Adams MM, and Keil DE. 2015. Immunotoxic effects of perfluoroalkylated compounds: Mechanisms of action. In: Molecular Immunotoxicology (Corsini E and van Loveren H, eds). Wiley-VCH GmbH & Co., Weinheim.

 DeWitt JC and Dietert RR. 2014. Immunotoxicity in autism spectrum disorders. In: The Comprehensive Guide to Autism (Patel VB, Martin CR, Preedy V, and Preedy VR, eds). Springer Reference, New York, NY.

Dietert RR, DeWitt JC, and Luebke RW. 2012. Reducing the prevalence of immune-based chronic disease. In: Immunotoxicity, Immune Dysfunction, and Chronic Diseases (Dietert RR and Luebke RW, eds), Molecular and Integrative Toxicology, Springer Science + Business Media, LLC. pp 419-440.

DeWitt J, Peden-Adams M, Keil D, and Dietert R. 2012. Developmental immunotoxicity (DIT): Assays for evaluating effects of exogenous agents on development of the immune system. In: Current Protocols in Toxicology. Chapter 18: Unit 18.15.

Luebke RW, DeWitt JC, Germolec DR, Salazar KD, and Kerkvliet NI. 2012. Immunomodulation by persistent organic pollutants. In: Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3nd Edition (Schecter A, ed), John Wiley and Sons, Inc., Hoboken, NJ. pp 171-192.

DeWitt JC and Dietert RR. Postnatal immune dysfunction and its impact on growth parameters. 2012. In: Handbook of Growth and Growth Monitoring in Health and Disease (Preedy VR, ed), Springer, New York, NY. pp 741-755.

 DeWitt JC and Luebke RW. 2010. Immunological Aging. In: Comprehensive Toxicology, 2nd Edition, Volume 5 (Lawrence D, ed), Elsevier Limited, Oxford, UK. pp 455-465.

Dietert RR and DeWitt J. 2010. Developmental immunotoxicity (DIT): The why, where and how of DIT testing. In: Immunotoxicity Testing: Methods and Protocols (Dietert RR, ed), Methods in Molecular Biology. Humana Press, Inc., Totowa, NJ. 598:17-25.

Luebke RW, Beamer CA, Bowman C, DeWitt JC, Gowdy K, Johnson VJ, Shepherd DM, and Germolec DR. 2009. Immunotoxicology (developmental immunotoxicology section). In: General and Applied Toxicology, 3rd Edition (Marrs T, Ballantyne B, Syversen T, eds.), John Wiley & Sons, Ltd., Chichester, UK, pp 1561-1583.

Other Scholarly Contributions
DeWitt, JC (ed). 2015. Toxicity of Perfluoroalkyl and Polyfluoroalkyl Substances. Springer Science + Business Media, LLC.

Portier CJ et al. (90+ co-authors). 2016. Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). Journal of Epidemiology and Community Health. 70:741-745.

DeWitt JC and Luebke RW. 2014. Immunological Aging. Online Reference Database Biomedical Science.

Benbrahim-Tallaa L, Lauby-Secretan B, Loomis D, Guyton KZ, Grosse Y, El Ghissassi F, Bouvard V, Guha N, Mattock H, and Straif K on behalf o the International Agency for Research on Cancer Monograph Working Group (DeWitt JC, Mechanisms Subgroup Member). 2014. Carcinogenicity of perfluorooctanoic acid, tetrafluoroethylene, dichloromethane, 1,2-dichloropropane, and 1,3-propane sultone. The Lancet Oncology. 15:924-925.

IARC. 2014 Perfluoro-octanoic acid, Tetrafluoroethylene, Dichloromethane, 1,2-Dichloropropane, and 1,3-Propane sultone. IARC Monogr Eval Carcinog Risks Hum (DeWitt JC, Mechanisms Subgroup Member). Monograph 110.

DeWitt JC and Dietert RR. 2011. Response to “Theoretical aspects of autism: Causes – a review” by Ratajczak, HV (Journal of Immunotoxicology 8:68-79, 2011). Journal of Immunotoxicology. 8:195-197.

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